Download e-book for iPad: Advances in the Neuroscience of Addiction (Frontiers in by Cynthia M. Kuhn, George F. Koob

By Cynthia M. Kuhn, George F. Koob

ISBN-10: 0849373913

ISBN-13: 9780849373916

This can be a great evaluate of the present realizing of the mind platforms and chemistry concerned with dependancy. a data of neuroanatomy and neurochemistry in addition to genetics is presumed.

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Additional resources for Advances in the Neuroscience of Addiction (Frontiers in Neuroscience)

Example text

It is thus possible to use the procedure to test for differences in single neuron activity across relatively small subregions of a given structure (Uzwiak et al. 1997; Hollander and Carelli 2005; Peoples et al. 2007b). 5 Example of a raster and histogram display for a single neuron. Top: A raster display marks the occurrence of each discharge of a particular neuron for 15 cocaine­reinforced lever presses. Each tick corresponds to a single discharge. Each row shows all the discharges during the 10 sec before and after each of the 15 lever presses.

2 Basic Method................................................................................................... 3 Rationale, Advantages, and Disadvantages of the Method............................. 1 Importance of Electrophysiological Investigations for Identifying Causes and Treatments of Addiction........................... 4 An Integrated Electrophysiological Approach.................................... 4 Application of the Method: Differentiating Pharmacological and Nonpharmacological Effects and Testing Addiction Hypotheses...................

These include but are not limited to the state of depolarization, the firing rate of a neuron, and the identity of afferent input to a neuron at the time of drug exposure (O’Donnell et al. 1999; Floresco et al. 2003; O’Donnell 2003; West et al. 2003). There is a potential for marked differences in the state of these variables between behaving animals and either the slice or the anesthetized animal preparations. In both the slice and anesthetized animal preparations, individual neurons can be cut off from normal afferent input.

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Advances in the Neuroscience of Addiction (Frontiers in Neuroscience) by Cynthia M. Kuhn, George F. Koob


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